Therapeutic Efficacy of Rubus Ellipticus (smith) Fruits Extracts in Acute Acetaminophen Induced Nephrotoxicity in Rats
نویسندگان
چکیده
The aim of the present investigation was to investigate the nephro-protective activity of fruits extracts of Rubus ellipticus (Smith) at a dose of 200 mg/kg body weight on acetaminophen (APAP) induced naphro-toxicity in male albino rats. APAP significantly increased the levels of serum creatinine, serum urea, blood urea nitrogen and kidney weight while the volume of urine reduced. The pet.ether, ethanolic and aqueous extracts of Rubus ellipticus fruits significantly (p<0.05, p<0.01) normalized the above said biochemical parameters increased or decreased by the oral administration of APAP (750 mg/kg body weight). Apart from these, histopathological changes also showed the protective nature of the Rubus ellipticus fruits extracts against APAP induced necrotic damage of renal tissues. In conclusion it was observed that all the fruits extracts of Rubus ellipticus conferred nephroprotective activity as evidenced by histopathological and biochemical observations against APAP induced renal damage in rats.
منابع مشابه
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